Abstract Search

ea0065p273 | Neuroendocrinology | SFEBES2019

Tissue responsiveness to cortisol: a novel clinical biosignature for the prediction of Nelson’s syndrome

Das Liza , Walia Rama , Bhansali Anil , Dutta Pinaki , Mukherjee Kanchan Kumar

Introduction: Nelsons syndrome is a significant long-term complication of bilateral adrenalectomy for Cushings disease. However, evidence about possible factors that can predict its occurrence, is controversial and limited.Objective: The objective of this analysis was to elucidate the role of various factors in prediction of Nelsons syndrome and the extent of their modifying effect.Methods: All patients with Cushi...

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ea0025p127 | Diabetes, metabolism and cardiovascular | SFEBES2011

Utility of glycated haemoglobin in diagnosing prediabetes in Asian Indians- A Community Survey: Chandigarh Urban Diabetes Study (CUDS) group

Padala Ravikumar , Bhansali Anil , Walia Rama , Ravikiran M , Sunder G , Bhansali Shobhit , Bhadada Sanjay , Dutta Pinaki

Aim: To determine the HbA1c cut-offs for diagnosis of prediabetes based on isolated IFG, isolated IGT and both IFG and IGT.Methods: Cross-sectional randomized population survey involving 2368 adults, aged ≥20 years. HbA1c was measured on a Bio-Rad 10 system in 1972 subjects.Results: Among 1972 studied subjects, 329 were detected to have prediabetes based on isolated IFG in 125 (6.3%), isolated IGT in 141 (7.1%) and both in 63...

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ea0073oc8.2 | Oral Communications 8: Pituitary and Neuroendocrinology | ECE2021

Osilodrostat is an effective and well-tolerated treatment option for patients with Cushing’s disease (CD): Final results from the LINC3 study

Fleseriu Maria , Biller Beverly , Pivonello Rosario , Akira Shimatsu , Carla Scaroni , Belaya Zhanna , Vila Greisa , Houde Ghislaine , Walia Rama , Izquierdo Miguel , Roughton Michael , Pedroncelli Alberto , Newell-Price John

IntroductionOsilodrostat, a potent oral 11β-hydroxylase inhibitor, normalized mean urinary free cortisol (mUFC) in most patients with CD during the 48-week (W) core phase of a Phase III study (LINC3: NCT02180217). We present efficacy and safety results following an extension to LINC3.MethodsCD patients with mUFC > 1.5× upper limit of normal (ULN) received osilodrostat during the core. Patients b...

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ea0077p223 | Neuroendocrinology and Pituitary | SFEBES2021

Generation of normative data on serum insulin-like growth factor I (IGF-I) in healthy school children of a north indian city

Dutta Pinaki , Teja KV Ravi , Aggarwal Arun , Sachdeva Naresh , Malhotra Bhanu , Das Liza , Walia Rama , Rastogi Ashu , Bhansali Anil , Bhadada Sanjay , Pal Rimesh , G Dewan , Marwaha R K , Monaghan Phillip , Trainer Peter , Korbonits Marta

Context: To diagnose and monitor GH-related disorders, serum IGF-I is a cornerstone, but Indian ethnicity based data, following consensus criteria for establishment of normative data are not available.Objectives: To generate normative IGF-I data for chronological age, bone age (BA) [Greulich & Pyle] and Tanner stage for both genders.Setting and Participants: We conducted a cross-sectional epidemiological study for children (age...

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ea0081ep698 | Pituitary and Neuroendocrinology | ECE2022

Age and puberty based IGF-1 normative data in healthy children from North India.

Malhotra Bhanu , Teja Kv Ravi , Bhadada Sanjay , Rastogi Ashu , Bhansali Anil , Sachdeva Naresh , Minz Ranjana Walker , Walia Rama , Prakash Mahesh , Aggarwal Arun Kumar , Dewan Gajinder , Das Liza , Monaghan Philip , Trainer Peter , Korbonits Marta , Marwaha Raman Kumar , Dutta Pinaki

Context: Serum IGF-1 levels are of paramount importance for diagnosis and management of growth related disorders. The reference range of IGF- 1 should be ethnicity and Tanner specific. Indian data on the same is scarce and there is a need to develop the same.Objective: To develop age, sex and Tanner based normative reference range of serum IGF-1 level for Indian children and correlate the same with peri-pubertal hormonal parameters.<p class="abstext"...

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ea0090p696 | Pituitary and Neuroendocrinology | ECE2023

In the Phase III studies LINC 3 and LINC 4, osilodrostat was effective and well tolerated in patients of Asian and non-Asian origin with Cushing’s disease

Akira Shimatsu , Biller Beverly M.K. , Fleseriu Maria , Pivonello Rosario , Jig Lee Eun , Rattana Leelawattana , Hee Kim Jung , Walia Rama , Yu Yerong , Liao Zhihong , Piacentini Andrea , Pedroncelli Alberto , Snyder Peter

Introduction: Osilodrostat (oral 11β-hydroxylase inhibitor) demonstrated rapid, sustained cortisol normalisation in Phase III studies (LINC 3, NCT02180217; LINC 4, NCT02697734) in patients with Cushings disease (CD). Relative osilodrostat bioavailability is ~20% higher in Asian patients than other ethnicities; body weight is not a major determinant of this difference. This analysis of LINC 3 and LINC 4 evaluated osilodrostat efficacy and safety in Asian and non-Asia...

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Endocrine Abstracts

Tissue responsiveness to cortisol: a novel clinical biosignature for the prediction of Nelson’s syndrome

Utility of glycated haemoglobin in diagnosing prediabetes in Asian Indians- A Community Survey: Chandigarh Urban Diabetes Study (CUDS) group

Osilodrostat is an effective and well-tolerated treatment option for patients with Cushing’s disease (CD): Final results from the LINC3 study

Generation of normative data on serum insulin-like growth factor I (IGF-I) in healthy school children of a north indian city

Age and puberty based IGF-1 normative data in healthy children from North India.

In the Phase III studies LINC 3 and LINC 4, osilodrostat was effective and well tolerated in patients of Asian and non-Asian origin with Cushing’s disease

BiosciAbstracts